All posts tagged drug

  • Guardian Australia story: ‘”His Death Still Hurts”: Pfizer anti-smoking drug Champix ruled to have contributed to suicide’, September 2017

    A feature story for Guardian Australia. Excerpt below.

    ‘His Death Still Hurts’: the Pfizer anti-smoking drug ruled to have contributed to suicide

    An Australian coroner says Champix had a role in Timothy John’s death, which occurred after only eight days on the drug

    '"His Death Still Hurts": the Pfizer anti-smoking drug ruled to have contributed to suicide" by Andrew McMillen on Guardian Australia, September 2017

    When the retired Queensland schoolteacher Phoebe Morwood-Oldham started an online petition following her son’s suicide in April 2013, she could not have known that her insistence on asking hard questions of one of the world’s largest pharmaceutical companies would lead to an Australian-first finding by a state coroner.

    On Thursday in Brisbane magistrates court, coroner John Hutton found that a commonly prescribed drug named Champix – manufactured by Pfizer and sold internationally under the name Chantix – contributed to the death of a 22-year-old Brisbane man, Timothy John, who died by suicide soon after he began taking a medication that he had hoped would cut his smoking habit from eight cigarettes a day down to zero.

    For Morwood-Oldham, the finding was a satisfying outcome for a lengthy process that began with a Change.org petition that she started four years ago, which asked for on-the-box warning labels on Champix packaging. It has been signed by 49,000 people. “His death still hurts so deep,” she wrote at the top of the petition. “After taking the anti-smoking drug marketed as ‘Champix’ for just 8 days, my beautiful boy hung himself. But despite reports of 25 suicides linked to Champix in seven years – there still aren’t proper side-effect warnings.”

    Every Sunday for four years Morwood-Oldham and her older son, Peter, have visited Timothy’s grave at Cleveland cemetery. The weekly routine involves the laying of lillies and turning their minds toward a young man who was, as his headstone says, “much wanted and loved”. Morwood-Oldham tells Guardian Australia that Timothy’s death “was so sudden” and it affected her deeply.

    “I lost the person I love the most in the world, in eight days. I never expected it.”

    Talking about Timothy, Morwood-Oldham warns that her emotions are “all over the place”. He is never far from his mother’s mind, nor her gaze: when she opens her laptop to share some photographs, there he is, her screensaver. A cute, blond boy aged six, aiming a cheeky smile at the lens.

    Timothy had suffered mental health issues, something his mother speaks of in terms of grades out of 10. He had for a time been a 4/10, then, after cognitive behaviour therapy, he was back to 9/10.

    “How did he go from a 9/10 to a 1/10 in eight days on Champix?” she said. “The autopsy showed there were no alcohol or drugs in his system other than Champix and Ibuprofen.”

    The inquest heard that, on a drive back from the Gold Coast just hours before his death, Timothy asked, “Mum, do you think I should give up the Champix? It’s making me feel strange.” Morwood-Oldham told the original two-day inquest in November last year: “I said to him, ‘Timothy, if it’s helping you to give up smoking maybe you keep it up’.” She had not been part of the consultations with her son’s GP when he was prescribed the drug and the Champix packaging did not contain warnings for any potential adverse effects.

    To read the full story, visit Guardian Australia.

    For help if you are in Australia: Suicide Call Back Service 1300 659 467; ­Lifeline 13 11 14, Survivors of Suicide Bereavement ­Support 1300 767 022. For help if you are outside of Australia, visit suicide.org’s list of international hotlines.

  • Good Weekend story: ‘Trips To Remember: Psychedelic drug use and bad trips’, June 2017

    A story for Good Weekend magazine, published in the June 3 issue. Excerpt below.

    Trips To Remember

    They call themselves “psychonauts” – people who use drugs like LSD to embark on journeys of self-discovery and creativity. But how wise is it to go on a trip after life has taken a bad turn?

    Good Weekend story by Andrew McMillen: 'Trips To Remember: Psychedelic drug use and self-improvement', June 2017

    A few days before Christmas last year, two friends and I planned to take LSD together. We set a date and location: 10am Saturday morning, in a comfortable home, with a sober friend to keep a wary eye on us. The three of us are fit, healthy men in our late 20s; we are university graduates now employed in our respective fields. We have stable relationships, strong senses of self and a shared interest in occasionally ingesting substances that we know will twist our perceptions of the world in strange and fascinating ways.

    It would be a trip to remember. In my mind, I had already started rehearsing the day. The tiny cardboard squares of “blotter acid” would be removed from the freezer, carefully cut with scissors and placed beneath our tongues. The chemicals on the cardboard would be gradually metabolised by our bodies, before the pieces were chewed up and swallowed.

    For eight to 12 hours, the shared experience would further solidify our friendships. The LSD’s visual effects would make the walls and ceiling seem to bend and swoon. Colours would become intensified. It would inhibit our need to eat and drink and impair our sense of time.

    In conversation, our minds would make unexpected leaps between subjects, drawing inferences and relations that we might not have ordinarily seen. These leaps might make little sense to our sober friend, but perfect sense to us. In quieter moments, we would query the order and routine of our lives. Were there efficiencies to be made, or changes necessary?

    We would also laugh a lot – no doubt about that – and we would hear our favourite songs with ears attuned to different frequencies.

    Just a few days before the scheduled Saturday, however, I experienced a major professional disappointment. A writing project to which I had devoted more than a year of work would not be published. My self-confidence was shaken to its core, and despite unerringly good advice and support from those closest to me, I entered a period of mourning wherein I found myself questioning everything, even the wisdom of taking drugs that had been helpful before.

    To read the full story, visit Good Weekend.

  • Matters Of Substance story: ‘The Snowball and the Avalanche: Medical Cannabis in Australia’, July 2016

    A feature story for the May 2016 issue of Matters Of Substance, the quarterly magazine published by the New Zealand Drug Foundation. Excerpt below.

    The Snowball and the Avalanche: Medical Cannabis in Australia

    Stories of personal suffering, where debilitating symptoms are eventually eased by medical cannabis, are appearing ever more frequently in the news. Andrew McMillen argues it is these sorts of stories that have engendered compassion in Australia, eroding the stigma around medical cannabis use and paving the way for science and more evidence- based legislation.

    Matters Of Substance story: 'The Snowball and the Avalanche: Medical Cannabis in Australia' by Andrew McMillen, July 2016

    The story of medical cannabis in Australia is much the same as in other countries around the world that have tiptoed this path before us. Here across the ditch, as in New Zealand, the United States and many other advanced economies, it is a situation where two strange bedfellows have been pitted against one another: stigma and science. For many years, because of their preconceived attitudes, staunch opponents of illicit drug use have remained wilfully blind to the benefits of medical cannabis experienced by sick people. Here, as elsewhere, this is not a campaign for the impatient. Change is slow, often painfully so, as it relies on a willingness for opponents to reconsider their positions in light of compelling evidence.

    In the last few years, though, the situation has appeared to change rather quickly and dramatically. The appropriate image is that of a single snowball rolling down a hill, gradually gaining mass and momentum until it forms an unstoppable avalanche. To this end, a raft of touching personal stories have been told in the national media. As a result, many state and federal politicians have sensed a shift in public sympathy towards sick people who are attempting to access medical cannabis without further complicating their lives by crossing paths with the criminal justice system.

    Support for plant-based medicine has gone mainstream, as evidenced by a July 2014 ReachTel poll that found that almost two-thirds of Australians believe cannabis should be made legal for medical purposes. It is telling that compassion is the driving emotion here, rather than fear – long-time advocates might well wish they had cottoned on to this tactic earlier.

    These personal stories don’t come more dramatic and heart-wrenching than Dan Haslam’s. In fact, his journey to accepting and using medical cannabis has become emblematic of changing attitudes to the drug across Australia. Dan was the snowball, and his descent down the hill began when he was diagnosed with terminal bowel cancer in February 2010 while living in the regional New South Wales (NSW) city of Tamworth. There, the then 20-year-old eventually discovered that the only treatment that soothed his nausea and stimulated his appetite while undergoing chemotherapy was cannabis. His parents wished there was another way. The fact that his father was head of the Tamworth Police Drug Squad made this desperate decision even more ethically and legally tortured than usual.

    To read the full story, visit Matters Of Substance.

    Further reading: my book Talking Smack: Honest Conversations About Drugs, published by University of Queensland Press in 2014.

  • The Weekend Australian Magazine story: ‘Tall Poppies: Tasmanian opiates’, March 2015

    A story for the March 7 issue of The Weekend Australian Magazine. Excerpt below.

    Tall Poppies

    It supplies up to half the world’s legal opiates, but Tasmania’s poppy industry sees danger ahead.

     The Weekend Australian Magazine story: 'Tall Poppies: Tasmanian opiates' by Andrew McMillen, March 2015

    Perched in a corner of Keith Rice’s office, atop a cupboard and behind a bright yellow hard-hat, sits an old white sign that warns of grave peril.DANGER. Prohibited area. KEEP OUT. Trespassers ­prosecuted.

    In front of it, an updated version includes a skull-and-crossbones captioned POISON. In bold red text, the bottom of the new sign reads: ILLEGAL use of crop has caused DEATH. This recent shift in tense — “may cause” to “has caused” — came after three deaths from poppy misuse in the last three years here in Tasmania. Clearly, something had to change, beginning with the signage that borders roadside poppy crops.

    Rice, chief executive of Poppy Growers ­Tasmania, keeps glancing at the sign as we chat over coffee on a cool Launceston morning. A tall 66-year-old with tanned features and thinning white hair, he’s talking me through the complex web of politics, painkillers and, more recently, protectionism in which he has been involved for nearly 30 years.

    Above Rice’s desk hangs a wall calendar ­bearing a colour photograph of green countryside flanked by snowy mountaintops, as well as the name of Tasmanian Alkaloids, one of two pharmaceutical companies to have invested heavily in the poppy industry. It has been a big earner for the state, which grows up to 50 per cent of the planet’s legal ­opiates — from which morphine, codeine and thebaine can be extracted — that relieve the pain of humans throughout the world in the form of medicines such as OxyContin and Nurofen Plus. The warning signs are required by law to be displayed on all ­roadside paddocks to deter would-be drug experimenters from picking poppy heads and brewing the ill-gotten plants into a tea. “It’s a dangerous crop because you don’t know the alkaloid content,” says Rice. “Thebaine is like strychnine in your system.”

    Tasmania produces around 90 per cent of the world’s thebaine, which causes convulsions in humans at high doses. In the past two decades thebaine production has eclipsed the old fav­ourite, morphine. A more effective painkiller, ­thebaine is also much more dangerous, as two Danish backpackers found last February after stealing 40 poppy heads from a farm near ­Oatlands, in the centre of the state. The pair brewed the plant into a tea; one of the drinkers, a 26-year-old male, fell asleep and never awoke. In November 2012, morphine toxicity also killed a 17-year-old who stole five kilograms of poppy capsules from a farm at Lewisham, near Hobart, and consumed a poppy tea. In February 2011, a 50-year old man died in similar circumstances in the Launceston suburb of Ravenswood.

    Tasmania’s $100 million dollar poppy ­industry is hidden in plain sight: drive north from Hobart towards Launceston in the ­summer and rolling fields of white, pink and purple flowers dot the landscape. At its peak a few years ago, 30,000ha of poppies were planted in a season; that number is now closer to 20,000ha per year due to a dip in world demand following changes in US prescription policies arising from drug abuse.

    The pharmaceutical companies who pay farmers to grow their products have a long ­history on the island, but mainland state ­governments have been paying attention to the economic consistency of Tasmania’s poppy crop, too. Last September, then federal health minister Peter Dutton wrote to his state and ­territory counterparts asking them to revise a 43-year-old agreement that has restricted poppy production to the island. Soon after, legislation was passed in Victoria and the Northern ­Territory that allowed the narcotics to be grown under strict licensing conditions following small-scale commercial trials during the 2013-14 season.

    It’s a worrying development for Tasmanian farmers who for more than four decades had cornered a secure and lucrative market. The path of Tasmania’s poppy industry so far has been one of prosperity and productivity, with the occasional pothole when misuse of the crop has caused death, or when heavy rains have ruined crops or a mildew outbreak occurs, as it did last November. The great unknown is how big a pothole the mainland expansion will be in the state’s proud history of painkiller production.

    To read the full story, visit The Australian.

  • Rolling Stone story: ‘Building A Better Brain: Wired on Nootropics’, November 2012

    A 4,000 word feature story published in the November 2012 edition of Rolling Stone Australia; my first non-music feature for the magazine. Click the below image to view a PDF version, or scroll down to read the article text.

    Building A Better Brain: Wired on Nootropics
    By Andrew McMillen / Illustration by Amanda Upton

    A new generation of “smart drugs” that promise to enhance cognitive ability are now available, but are they the key to the human race’s next evolutionary leap or merely 21st century snake oil? Rolling Stone finds out…

    Before he swallowed the designer drug NZT, Bradley Cooper was having a shitty day. Scratch that; he was having a shitty life. Cooper was an unproductive, depressed writer with few prospects and fewer friends. His long-suffering girlfriend had recently left him. His unkempt appearance implied that his deep apathy extended to his body image. Here was a man broken by the accrued stress and malaise of living a seemingly pointless, joyless existence in modern day New York City.

    Moments after taking the transparent, odourless NZT pill, though, Cooper’s world changed dramatically. His visual and auditory perceptions sharpened significantly. His brain could instantly summon previously forgotten snatches of glanced-at facts and figures. His empathy and charm were suddenly amplified to the point where he was able to bed a woman who previously loathed him. A burst of inspiration saw him cleaning his apartment for the first time in years while forgoing both food and his usual addiction to nicotine. Within a few hours, Cooper produced a hundred pages of brilliant writing, which pleased his editor like never before.

    As his interior monologue put it, “I was blind; now I see. I wasn’t high, wasn’t wired; just clear. I knew what I needed to do, and how to do it.”

    This isn’t a scene from Bradley Cooper’s actual life, of course. It’s the life of a fictional character named Eddie Morra, which Cooper portrayed in the 2011 thriller Limitless. Right now, I’m psyching myself up for a Bradley Cooper moment of my own. My version of the make-believe NZT is a little, white, very real pill named Modalert. Produced by Indian manufacturer Sun Pharmaceuticals, the drug’s generic name is modafinil and it costs around $2 per 200mg dose. In Australia, it’s only prescribed to narcoleptics and shift workers who have difficulty staying awake. I’ve acquired some through an online retailer and at 5pm on a Monday, I take the drug for the first time.

    By 10pm I’m wide awake, and aware that my resting heart-rate is higher than normal. By midnight my mind is racing around like an agitated puppy: “Hey! Here I am! Play with me!” I occupy myself with the normally tedious task of transcribing interviews; when I next look at the clock, it’s 3.30am and I’m finished. I’m washing dishes to take a break from work, when I realise that my randomly chosen soundtrack has taken on an eerie parallel to real life. In the classic Nas track ‘N.Y. State of Mind’, he raps: “I never sleep / ‘Cuz sleep is the cousin of death.”

    For as long as I can remember, my answer to that age-old ‘just one wish’ hypothetical has been ‘to never fatigue’. To never need to sleep. To be able to learn, create and achieve more than any regular human being because I’m no longer confined by the boring necessity of a good night’s sleep.

    Thanks to modafinil, I’m closer to this long-held dream than ever before. And I feel incredible. Not high, not wired; just clear. The computer in my skull is crunching ones and zeroes while the rest of the world sleeps. I yawn occasionally, but my mind feels focused, at capacity, even as 5am approaches.

    It’s a kind of cognitive dissonance I’ve never experienced before; I know I should be feeling fatigued by now, but everything’s still working well. At 8.30am – roughly fifteen hours after taking the drug, which corresponds with its stated half-life – its effects wear off, and fatigue sets in. I take a three-hour nap, then pop another modafinil upon waking. I’m back on the merry-go-round of sleeplessness, and loving it.

    Giddy at the near-endless productivity possibilities that I’ve suddenly unlocked, I confess my off-label use of Modalert to a Sun Pharma spokesperson via email in a moment of clarity (or, perhaps, over-earnest honesty). The reply arrives in my inbox a short time later, and I’m briefly quietened by its ominous tone.

    “You’ve seen Limitless?” the Indian drug rep replies. “The cost is too much. Please evaluate what you are doing, even for test purposes. Neuronal circuitry is not to be messed with.”

    ++

    Modafinil is the brightest star in a galaxy of drugs and supplements called ‘nootropics’. The word was coined by a Romanian doctor in 1972; in Greek, its definition refers to ‘turning the mind’. More commonly known as ‘smart drugs’ or ‘cognitive enhancers’, nootropics work in one of three ways: by altering the availability of the brain’s supply of neurochemicals; by improving the brain’s oxygen supply; or by stimulating nerve growth.

    Smart drugs are not a new concept. Last century, both cocaine and amphetamine were considered to have enhancement potential. As researchers at the University of Queensland wrote in a 2012 paper, “…their use for this purpose was regarded in a wholly positive light. [Cocaine and amphetamine] were seen as safe and effective ‘wonder drugs’ that increased alertness and mental capabilities, thereby allowing users to cope better with the increasing demands of modern life.” These views became unpopular once both substances were found to be addictive: cocaine became a prohibited substance, though amphetamine is still widely prescribed as a treatment for attention deficit hyperactivity disorder (ADHD) under the brand name Adderall.

    The Therapeutic Goods Administration (TGA), Australian drug regulation authority, does not yet recognise nootropics as a class of drug, as “the information available on nootropic products provides a very broad definition.” A TGA spokesperson tells Rolling Stone that they are unable to comment on the matter, as “the issue here is that the definition of nootropics goes from nutritional supplements all the way through to prescription medicines, so depending on what the product is and its claims, it might be considered as listable, a registered complementary medicine, or a registered prescription medicine.”

    So regulation is a murky topic, then. But nootropics aren’t illegal, either. Admittedly, taking modafinil off-label is not a smart thing to do. I am not a narcoleptic. I sleep just fine, if begrudgingly. I am a healthy 24 year-old male who exercises regularly and eats well. My recreational drug use is occasional. I’ve never been addicted to anything, and I intend to keep that clean sheet. I would like to be able to concentrate for long periods during the work week, though. I’d like to be able to instantly summon previously forgotten snatches of glanced-at facts. In short, I’d like to be smarter. Who wouldn’t?

    In the fictional account of Limitless and its inspiration, a 2001 techno-thriller by Irish author Alan Glynn named The Dark Fields, the universally appealing idea of self-improvement through minimal effort is explored by a guy taking a designer drug to boost his brainpower to superhuman levels. In reality, nootropic enthusiasts claim significant cognitive benefits with few, if any, side effects from taking these supposedly non-addictive, non-toxic substances.

    Sounds too good to be true? You bet. With my bullshit detector cranked up to eleven, I’m wading into this contentious field with the goal of separating science from fiction. Are smart drugs the snake oil of the 21st century? Or am I about to become a better man just by taking a bunch of coloured pills?

    ++

    After Eddie Morra tires of writing while under the influence of NZT, he turns his attention to the far more lucrative stock market. When I tire of writing on modafinil, I waste away the night-time hours by shooting terrorists in Counter-Strike: Source online, trawling internet forums, and reading about nootropics.

    With a newfound surplus of time arises an interesting dilemma: how to spend it? I chose to alternately work, read, and play games. What if every night was like that, though? What if I had all that time? How soon would I become accustomed to operating on little, or zero, sleep? What would be the side-effects of this for my health, my relationships, my career? Would I become a kinder person? Would parts of my personality become amplified, or atrophy? Obvious productivity gains – or productivity opportunity gains – aside, would less sleep make me a better person?

    All Tuesday night, I’m keyed into a writing task with laser-like focus. By sunrise, I’ve produced an article which, at the time, feels like some of my best work yet. (When it’s published online, weeks later, I read it with fresh eyes and I’m pleasantly surprised to find that I still feel the same way.) On Wednesday, I choose to take a break from the drug, but I’m still up until 4am. My sleep cycle has been totally disrupted.

    Thursday just feels like a regular day. I’m yawning more than usual, probably due to the sleep debt I’ve incurred this week. But it does feel a little… boring to be operating at this level, rather than on modafinil, where I feel like I’m connecting all of the dots all of the time. I suddenly find myself weighing up the costs and benefits of taking a pill right now. I have nothing in particular that needs to be completed for the remainder of the week, but there’s an internal argument happening: “Being awake is so much more enjoyable than sleeping. Who needs sleep, honestly?”

    I dose another 200mg, and within the hour, I again find myself making connections in music that I’d never previously noticed. The Black Rebel Motorcycle Club song ‘Stop’ aligns with my current mindset: “We don’t know where to stop / I try and I try but I can’t get enough…

    I feel like an outlaw; as though I’m in on a secret to which everyone else is oblivious. I know how to subvert sleep; that knowledge is in the shape of a small white disc containing 200mg of modafinil. I feel as though taking this drug might be one of the best decisions I’ve ever made. I want everyone around me to take it, too, so that we can share our experiences and revel in the euphoria of the unclouded mind.

    That night, I drive to and from a rock show. I meet friends and strangers at the venue; as I talk, I feel as though I’m not making sense, and that those around me are acutely aware of this. I feel in control, but my mind is racing faster than my mouth can keep up. I buy one beer and feel a little drunk, but I don’t come close to crashing my car on the drive home. Around 2am, I note that I’ve got an impending feeling of doom going on. Like I’m riding this too far, and it’s about to start doing some serious damage. I turn in at 3.30am on Friday.

    My first nootropic odyssey whimpers to a close, after beginning with a giddy bang at 10am on Monday morning. I’ve taken three 200mg doses of modafinil during that time – 5pm Monday, 1pm Tuesday, 2.30pm Thursday – and napped for around 11 hours total. In all, I’ve been awake for 79 out of the last 90 hours.

    I arise at midday, refreshed, having effectively reset my debt with one normal sleep. I reflect on how my views toward modafinil have veered between utter devotion to, now, in the cold light of day, a realisation that it’s probably not a good idea to be taking that shit on consecutive days. I was feeling so fucking average the night before. I couldn’t bear the thought of continuing to stay awake. The body and the mind aren’t made for it.

    ++

    Next, I purchase some homemade nootropics from a vendor named Tryptamine on Silk Road (SR), an anonymous online market where illicit drugs are purchased with virtual currency and sent through the international postal system. Tryptamine’s vendor profile states, “I am a biologist who develops nutritional supplements to improve your health, sleep, and cognition. I use only natural or orthomolecular ingredients, and no adverse effects have been reported from my products.”

    Tryptamine makes and sells three nootropics. I order two 24-pill bottles of MindFood (“designed to optimize brain function, protect against stress- and drug-induced neurotoxicity, prevent/alleviate hangovers, and reverse brain aging,” among other alleged effects), and ChillPill (“designed to promote relaxation, attenuate stress, calm excess brain activity, enhance mood, and promote dreaming”). The seller kindly includes a bonus five-pill sampler of ThinkDeep (“designed to stimulate brain metabolism and glucose uptake, improve memory formation/recall, expand attention span, prevent mental fatigue and enhance blood flow”), too.

    The total cost is around AUD$100. As I pay this seemingly exorbitant amount, I’m reminded of that old aphorism about fools and their money. The package lands in my mailbox via the state of New York around two weeks later. The pills are brightly coloured and strong-smelling. I try all three nootropics in isolation, one or two at a time, on different days.

    After swallowing a ThinkDeep for the first time, I realise that I just took an anonymous black and red pill created by an anonymous internet seller who claims to be a biologist. They’ve got a 100% feedback record from over 400 transactions on SR, which counts as a sort of social proof, but still: bad things could happen to me after taking this pill, and the person responsible would never be caught out. (Tryptamine denied Rolling Stone’s request to verify his/her identity, or scientific credentials. “Whatever image you have in your mind’s eye from reading this, that’s how I look,” the seller wrote.)

    “Silk Road allows me to sell my products anonymously, and provides me with hundreds of thousands of potential customers who already take pills that aren’t made by pharmaceutical companies,” Tryptamine tells me. “On the other hand, it is a bit off-putting to see my products listed beside bags of heroin.”

    As it turns out, ThinkDeep doesn’t do much for me, even on another day when I double-dose. In fact, the only significant effect I notice from these three products is when one dose of MindFood eradicates a hangover much faster than my regular methods of paracetamol and/or ibuprofen. Perhaps ThinkDeep and ChillPill are so subtle that I don’t notice their effects; perhaps they don’t work at all. Potential hangover cure aside, it’s difficult to recommend these products for cognitive enhancement purposes.

    At the other end of the nootropic spectrum, far from secretive biologists and solo recipe-tweaking, is an Austin, Texas-based company named Onnit. Their flagship product is named Alpha Brain, which is slickly marketed as a “complete balanced nootropic”. Their biggest public advocate is the comedian, podcaster and former host of Fear Factor, Joe Rogan; they also have a few World Series of Poker players hyping the product on their website. I ordered a 30-pill bottle of Alpha Brain for around $40.

    Each green pill includes small amounts of eleven impressive-sounding substances, from vitamin B6 and vinpocetine, to L-theanine and oat straw. The serving size on the label suggests two pills at a time; as I discover, taking one does nothing. With two Alpha Brain pills circulating in my system, though, I feel an overall mood elevation and a heightened ability to concentrate on tasks at hand: reading, writing, researching. These effects last for between four to six hours.

    Alpha Brain worked for me, but it also feels like a triumph of marketing, too. As there are no clear estimates about the financial side of the nootropics industry, I ask Onnit CEO Aubrey Marcus whether it’s a lucrative field. “Absolutely,” he replies, though he won’t comment on Onnit’s annual turnover. “It’s something that everybody can benefit from. Whenever you tap into something [like that], there’s ample opportunity to make good money.” Marcus says that Alpha Brain has been purchased by around 45,000 customers across the world since launching last year. The company currently employs 13 full-time staff.

    He acknowledges that nutritional supplement manufacturers are met with their fair share of critics. “The pharmaceutical industry has done a good job of telling people that synthetic drugs are the only things that have an effect on the body. There are plenty who’ve never tried our products who’ll swear that they’re snake oil,” Marcus laughs. “We encounter that, and we just do our best to show as much research behind all the ingredients that we have.” He mentions that Onnit are intending to commission a double-blind clinical study on the effects of Alpha Brain, which he believes “will go a long way to silence the critics.”

    ++

    Perhaps nootropics aren’t a mainstream concept yet because the people most enthusiastic about their potential benefits are all scientists, marketers out to make a buck, ‘body hackers’, and other weirdoes. There are few ‘normals’ taking these drugs and supplements on a daily basis, so it all looks too strange and confronting for outsiders to try. As a society, we’re taught by our peers and the media that if something sounds too good to be true, it probably is.

    There’s also the possibility that nootropics will never become mainstream because their effectiveness is difficult to qualitatively measure, or alternatively, they don’t work at all. In this regard, Australian researchers are world-class sceptics of cognitive enhancement. When I visit the University Of Queensland’s Centre for Clinical Research (UQCCR) in Brisbane, I’m greeted by Professor Wayne Hall, who was first published on this topic in 2004. His essay, which appeared in a European biology journal, was entitled “Feeling ‘better than well’: Can our experiences with psychoactive drugs help us to meet the challenges of neuroenhancement methods?”

    Hall has studied addiction and drug use for over 20 years. “There’s been a fair amount of enthusiasm for cognitive enhancement [in scientific circles], but it hasn’t looked critically at the evidence on how common this behaviour is,” he says. The professor and his peers argue for “taking a step back, and not getting too excited or encourage unwittingly lots of people to experiment with stimulant drugs for the wrong sorts of reasons”.

    “If you look at the lab studies that have been done on whether these drugs [work], the effects – insofar as there are some – are fairly modest and short-lived,” Hall says. “To be jumping from that, to saying it’s good idea for people to be using these drugs regularly to enhance their cognitive performance, is a bit of a long bow.”

    Dr Bradley Partridge is another UQCCR academic who specialises in investigating “the use of pharmaceuticals by healthy people to enhance their cognition”. I bring along my bottles of Alpha Brain and Tryptamine’s homemade nootropics for him to cast a critical eye over. “I have never used any of these things,” Partridge says. He peers at the labels with bemusement. “And I’ve never heard of most of these ingredients.”

    He places the bottles back on the table. “The thing is, a lot of these supplements are touted as being ‘all natural’, and for some people, that implies that they’re perhaps safe. But it’s very hard to evaluate exactly what’s in it. Aside from safety, where’s the evidence that they actually work for their stated purpose?”

    “There’s no scientific literature on some of this stuff; for others, the results are very mixed. Also, there might be a really strong placebo effect.” He holds up the Alpha Brain bottle, which mentions ‘enhancing mental performance’ in its marketing copy. “You take this and you do an exam; maybe simply taking something makes you feel like you ought to be doing better, and maybe you convince yourself that you’re getting some effect.”

    Hall and Partridge co-authored a study which analysed media reports on “smart drugs”. They found that 95 per cent of media reports mentioned some benefit of taking a drug like Adderall, Ritalin or modafinil, while only 58 per cent mentioned side effects. “I tend to be very cautious about this stuff,” Partridge says. “I don’t like to see this getting portrayed as a widespread phenomenon, as a fantastic thing, that it works, that there are no side effects. That runs the risk of encouraging people who hadn’t thought about it to take it up, which could cause problems for people.”

    I offer to leave some of my nootropics with Dr Partridge for him to conduct his own research; he laughs, and politely declines.

    ++

    Underscoring this entire discussion is the threat of one-upmanship. If I’m taking these drugs and they markedly improve my performance, am I nothing but a filthy nootropic cheater? To address this question, I spoke with Dave Asprey, who has used modafinil constantly for eight years and describes himself on Twitter as a “New York Times-published Silicon Valley entrepreneur/executive/angel who hacked his own biology to gain an unfair advantage in business and life.”

    Asprey has a prescription for the drug, after a brain scan showed a lack of blood flow at the front of his brain – a common symptom of attention deficit disorder (ADD), he says. “Modafinil is actually used commonly as a treatment for ADD,” he tells me. “It’s an off-label use, but it’s accepted; it’s even reimbursable by some insurance companies.”

    Asprey takes modafinil most workdays, upon waking. “It’s not like it’s a great secret out there, it’s just that people don’t talk about it because there’s some feel as though it’s ‘cheating’,” he says. “My perspective is different: if you eat healthy food, then you’re also ‘cheating’, because that impacts brain function. Surprisingly, the only people who’ve ever given me shit about taking modafinil are like, ‘but how do you know it’s not hurting you?’ I’m a bio-hacker; I’ve done all sorts of strange things to my body and mind in the interests of anti-aging, health and performance. I look at my body as part of my support system.’”

    Asprey says that he considers modafinil to be on the healthier spectrum of drugs. He’s also a fan of aniracetam, a fat soluble version of piracetam, which itself was the first-ever nootropic discovered in 1964. “It’s longer lasting [than piracetam],” Asprey says. “I recommend it as a basic biohack. I’ve been using it for a very long time.”

    Though Asprey has never met anyone who bluntly considers nootropics to be bullshit, he hears another argument reasonably often – and he has a clever rebuttal ready. “People say, ‘[nootropics] are evil, because if you take them, then everyone else will have to take them!’ I don’t think that’s a very fair argument, because from that perspective, fire is evil. Back when there were two cavemen, and one had a fire, the other said, ‘you can’t use fire, that’s unfair!’ Well, we know who evolved.”

    ++

    Whether or not I’m qualitatively smarter after experimenting with nootropics for this story is difficult to measure. I feel slightly wiser, and more aware of the limitations of both mind and body after that week of bingeing on modafinil. I certainly appreciate the restorative value of sleep better than ever before, after staying awake for the best part of a full work-week. I found that Alpha Brain is useful for focusing for a few hours, but considering that a two-week supply costs $40, it seems a touch on the expensive side.

    I did order a few dozen additional pills of modafinil, but I intend to use these only when emergency deadlines necessitate long hours. (I’ve read it’s good for combating the effects of jet lag, though, so perhaps I’ll try it on my next international flight.) Ultimately, the nootropic I found most useful – and intend to continue using regularly – is aniracetam, which Dave Asprey told me about. Its mind-sharpening effects are subtler than Alpha Brain, but it’s much cheaper – around $40 for a month’s supply if purchased online – and its effects taper off much more pleasantly than Alpha Brain’s comparatively sudden drop-off in concentration and energy levels.

    Late one night while researching this story, modafinil coursing through my body, I watched Limitless for the second time. It’s not a brilliant film, but it’s entertaining and thought-provoking enough to make the viewer consider seeking out smart pills of their own. It’s easy to see why the nootropic industry’s shadier sellers have attempted to draw parallels between their products and the fictional substance of NZT. After viewing the film, I contacted Alan Glynn, the author behind the 2001 techno-thriller The Dark Fields, which Limitless was based on, via email.

    “The original idea of NZT – called MDT-48 in my book – came from the idea of human perfectibility, of ‘the three wishes’, of the chance to re-invent yourself, of the shortcut to health and happiness,” Glynn tells me. “This is why the diet and self-help industries are so huge. Hold out a promise like that and people will respond. The fact that most of these products and therapies don’t work, or are bogus, doesn’t seem to matter. The real magic here, the real dark art, is marketing. I think that if nootropics ever go mainstream, they’ll be fodder for the marketing industry.”

    I send Glynn a link to the Alpha Brain website and mention that I’ve been taking it while researching this story. “Look, I’m just as much of a sucker as anyone else and when I look at that website, I’m going like, ‘Woah, gimme some of THAT!’” he replies. “And I’m actually seriously considering ordering some. So, from a marketing point of view, I’d say it’s a total success. It’s shiny, professional-looking and stuffed full of ‘the science bit’.”

    “But it’s the massaging of the science bit that is the marketer’s real dark art. The truth is, I couldn’t argue with someone who can talk about ‘GPC choline’ and ‘neurotransmitter precursors’. My instinct is that it’s all bullshit… On the other hand. I don’t know. Have you taken Alpha Brain? Does it work?”

    I reply in the affirmative, and describe my findings in some detail. Alan Glynn, author of the book that inspired the movie that inspired me to write this story in the first place, writes me back immediately: “That’s interesting indeed. I’ve ordered some Alpha Brain, and I’ve just got an email to say it’s been dispatched. I’ll report back to you – in the interests of science, of course.”

    Note: At no point should any of the products mentioned in this article be ingested without first consulting a health professional. An earlier version of this story incorrectly identified Ritalin as an amphetamine; it belongs to the methylphenidate class of stimulants.

    To read more on nootropics, I recommend that you continue your research at Smarter Nootropics. Good luck!

  • Australian Penthouse story: ‘The High Road: Silk Road, an online marketplace like no other’, February 2012

    A story for the January 2012 edition of Australian Penthouse, reproduced below in its entirety. Click the main image for a closer look (which will open a PDF in a new window), or read the article text underneath. You can click any of the below images and screenshots for a larger version, too..

    The High Road
    by Andrew McMillen

    Silk Road is an online marketplace like no other. Totally anonymous, the website uses sophisticated encryption software and a digital currency to facilitate the worldwide sale of prohibited items, particularly illicit drugs. Australian Penthouse investigates.

    “Imagine how exciting it is when you get something in the mail; even the shittiest thing, like a free sample. But in this case, you’re getting drugs that you really want to take, and get high on. It’s a compounded experience of excitement; an exponential high.”

    A 24-year old man who lives in an inner-city suburb of Brisbane is describing what he felt upon opening his mailbox one day in 2011 and discovering a package containing one gram of cocaine. It was addressed to a person who does not exist. He does not know the source of the substance beyond its country of origin. This was not the first time he had purchased drugs online; his first order was for one gram of MDMA powder. That package was sent to a house that he knew was unoccupied; it took around nine days to arrive from Canada. He checked the vacant mailbox daily. “I’m still waiting for some undies off of eBay from Hong Kong,” he says. “[The MDMA] arrived way quicker than that.”

    Why the alternate address in the first instance? “Because having something illicit sent in the mail seems fairly thick,” he replies. “It seems so simple; too good to be true. I wanted to put some form of buffer between myself and the order I made, as a ‘test run’.

    “One day it was in there and it hadn’t been intercepted. I didn’t get immediately arrested when I took it out of the mailbox. Since I didn’t use my real name, it didn’t seem possible to get traced back to me. It still hasn’t been.”

    These orders were made using a website called Silk Road. It can only be accessed after installing anonymity-enabling software called Tor. All purchases are made using Bitcoin, a currency which only exists online and whose public transaction history can be untraceable if handled correctly.

    My interviewee randomly discovered online mentions of Silk Road in May 2011, and pursued the intriguing concept all the way through to installing Tor and trading Australian dollars for Bitcoin; a process he calls “semi-prohibitive” owing to the persistence and tech-knowledge required to check all the boxes before users can place an order. In four transactions, my interviewee has ordered three grams of MDMA and three grams of cocaine at a cost of “close to AUD$700”.

    So what motivated him to take a chance on buying illicit substances online from a complete stranger?

    “I’m interested in taking drugs casually, but I hate the process,” he says. “I don’t know any dealers. Even if I want to get weed, I don’t know anyone, so it always becomes this drawn out process of finding someone who knows someone who knows someone. It’s a real pain in the arse. Whereas this way, it’s so direct and private. I didn’t leave my room, and then nine days later there was something in the mailbox that was for me. It’s discreet and exciting. Imagine the fun of shopping on eBay, but then you can also get high.”

    Visiting Silk Road for the first time, I feel a little like Alice falling down the rabbit hole. After downloading the correct Tor software bundle, I connected within five minutes. A warning appears at the bottom of the registration screen: “Be advised: This website is experimental. We do not guarantee your anonymity, protection from law enforcement in your jurisdiction, or protection from other users of this service. You and you alone are responsible for the risks associated with entering and using this website.” The site does not request any information from its users beyond a username and password; not even an email address. And then, you’re in.

    The site’s bright, clean design displays images of nine items for sale; among them, ‘red joker’ ecstasy pills, one-ounce of the ‘purple kush’ cannabis strain, a $50 Australian banknote and syringes. When I first visit the site in late August 2011, one bitcoin is worth USD$11.15; a fortnight later, the exchange rate has dropped to USD$6.18 per bitcoin.

    The nine ‘featured’ items change upon each page refresh. A column on the left categorises the goods for sale: ‘drugs’ is split into sub-categories like ‘dissociatives’ (11 items for sale), ‘psychedelics’ (123 items), ‘stimulants’ (65) and the most popular category, ‘cannabis’ (237). Other categories include ‘digital goods’, ‘money’, ‘XXX’, ‘weaponry’ and ‘forgeries’.

    At first, it’s a little overwhelming. What Silk Road [SR] offers is the online equivalent of strolling down a dim-lit alley filled with surly guys wearing heavy trenchcoats, except that you can contemplate purchasing their goods while lounging in your underwear, without fear of being stabbed.

    Each page on the site generally takes a few seconds to load, regardless of the user’s connection speed, due to an overcrowded Tor network. A page called ‘how does it work?’ describes the site as “an anonymous marketplace where you can buy and sell without revealing who you are. We protect your identity through every step of the process, from connecting to this site, to purchasing your items, to finally receiving them”. Lengthy guides for both buyers and sellers are freely available. The latter guide states that “every precaution must be taken to maintain the secrecy of the contents of your client’s package. Creatively disguise it such that a postal inspector might ignore it if it was searched or accidentally came open.”

    It concludes with a ‘final note’: “Regardless of your motivations, you are a revolutionary. Your actions are bringing satisfaction to those that have been oppressed for far too long. Take pride in what you do and stand tall.”

    There’s an active and boisterous SR forum community, which is hosted off-site and requires an additional registration; this process requests an email address, but a note states that it doesn’t have to be a legit address.

    After poking around the site and smirking at some of the items for sale – condoms, an e-book of Neil Strauss’ pick-up artist classic The Game, military training manuals – I decide to engage with a few sellers by requesting interviews using the site’s private messaging system.

    Within 10 minutes, three sellers respond enthusiastically to my request; one says, “I’ll even give you a media discount if you order.” The website’s administrator, who goes by the username Silk Road, also responds. “Sorry, we aren’t doing interviews at the moment,” he says. “Good luck.”

    Of the 27 SR sellers I approach during a two-week period on the site, seven respond thoughtfully and at length to my questions. They are mostly based in the US and Canada, though one is Australian. All seven request that I don’t mention their usernames. A few prefer to conduct the interview using PGP text encryption, which adds another element of spookiness to the situation. Most of the sellers found their way to Silk Road after the site was covered online by Wired and Gawker in June 2011.

    When I ask what they like about Silk Road, I’m met with a range of responses. “Being able to provide a safe and anonymous way for someone to purchase something that they choose to put into their body,” says one seller. “It’s nice how it turns drug dealing into an office job, with less risk and more stable demand while interacting openly with customers,” replies another. This focus on administrative duties is echoed by another seller, who says it’s “nice to have everything so organized and centralized, it really cuts down on the time spent per order which is a huge plus when you’ve got a mountain of them to work through.”

    One source remarked aloud, ‘this is the future’, upon finding the site. “The free market has provided for one of the oldest needs in human history,” they elaborate. “[SR] removes the elements of danger that exist in in-person black market arrangements, and offered anonymity for all parties involved.”

    I ask what sellers don’t like about the service. One tells me, “while the majority of users are honest and trustworthy, you always have to keep your guard up. There are plenty of scammers here on SR.” Another is frustrated by the long wait between making a sale and receiving the bitcoins in their account. “It can take a while for people to finalize transactions, so the money gets stuck in escrow until the customer remembers to finalize, or it auto-finalizes after like 20 or so days.”

    One seller is concerned about the silo-like nature of the site: “Having everything organized – vendor statistics easily accessible, reliance on a single server, etc – all makes any vendor, or even SR itself, a juicier target for LE [law enforcement].” An Australian seller replies, “I don’t like being out in the open. Even though I feel rather anonymous within SR, I could always make a simple mistake with my packaging or use of encryption that would give me away.”

    A few of my respondents reveal that they have sold drugs in the real world. One dubs the online process “much easier” than face-to-face sales. “SR buyers have no info about me whatsoever. Whereas with a face-to-face transaction, a buyer might know my name, what I look like, the car that I drive, or the city that I live in. So if they get caught, LE goes up the food chain. Here on SR, there’s nowhere for LE to go.”

    Another seller says SR is preferable because it “takes potential violence right out of the equation, and mitigates theft; you can’t exactly take someone to court for robbing you during a black-market trade, which is why there is so much violence. I prefer SR to offline, any day of the week.” One seller candidly replies, that SR is “better and cleaner. Customers are more educated and nice, and it leaves you more spare time to study, play with the kids, and clean the house. It’s telecommuting at its finest.”

    None of the seven sellers I interviewed would detail how they package the illicit substances sent through the international postal system. A couple mentioned that it’s an unwritten law among SR sellers to not disclose such methods, though I learn by reading the forums that vacuum sealing is common. The young man from Brisbane who received MDMA and cocaine in the mail didn’t want to discuss the appearance of the packages he received, either.

    All this illegal activity must be a rush, even if the process does become somewhat normalised due to the volume of orders that some sellers process. I have one final question. What does it feel like to sell illicit drugs over the internet to complete strangers?

    One replies, “honestly, it can be quite nerve racking. I have no idea if I just sent some illegal items to LE. That’s why it’s so important for a good vendor to use all precautionary tactics to keep important info away from them. Leaving no DNA or fingerprints, and sending from an area where you don’t live. It’s not unusual for a vendor to be wearing hairnets and multiple layers of gloves while packaging the material. If there is even a one-percent chance of some identifying marks on or inside that package, it will be thrown out.”

    Another says, “It’s awesome. Most of the users on Silk Road are good people, and it’s always been a pleasure providing them goods that their corrupt governments have denied them. By simply living our lives and doing what we want to do, we break the government’s iron fist. It’s pretty satisfying.”

    “It feels great,” agrees another. “I get to make a positive contribution in the lives of people who otherwise wouldn’t have access to drugs, such as old folks, and people in remote locations.” The seller shares some feedback received by a buyer that they found “really touching”. The feedback reads, “I don’t want to sound all sentimental and crap but in all honesty, my friends and I have become closer and happier with ourselves and each other, thanks to you and your stuff. It’s really been a bonding experience for everyone. We aren’t really the partying type and instead like to chill and talk for hours. Thanks to you, we have shared some amazing experiences.”

    The seller tells me that “getting feedback like that makes those nights spent sweating over a hot vacuum sealer seem worthwhile!”

    For more on Silk Road, visit its Wikipedia page.